Complet list of 1t0c hssp file
Complete list of 1t0c.hssp file
HSSP HOMOLOGY DERIVED SECONDARY STRUCTURE OF PROTEINS , VERSION 2.0 2011
PDBID 1T0C
THRESHOLD according to: t(L)=(290.15 * L ** -0.562) + 5
REFERENCE Sander C., Schneider R. : Database of homology-derived protein structures. Proteins, 9:56-68 (1991).
CONTACT Maintained at http://www.cmbi.ru.nl/ by Maarten L. Hekkelman
DATE file generated on 2014-05-09
HEADER HORMONE/GROWTH FACTOR 08-APR-04 1T0C
COMPND MOL_ID: 1; MOLECULE: INSULIN; CHAIN: A; SYNONYM: C PEPTIDE (SEQUENCE D
SOURCE MOL_ID: 1; ORGANISM_SCIENTIFIC: HOMO SAPIENS; ORGANISM_COMMON: HUMAN;
AUTHOR C.E.MUNTE,L.VILELA,H.-R.KALBITZER,R.C.GARRATT
DBREF 1T0C A 1 31 UNP P01308 INS_HUMAN 57 87
SEQLENGTH 31
NCHAIN 1 chain(s) in 1T0C data set
NALIGN 46
NOTATION : ID: EMBL/SWISSPROT identifier of the aligned (homologous) protein
NOTATION : STRID: if the 3-D structure of the aligned protein is known, then STRID is the Protein Data Bank identifier as taken
NOTATION : from the database reference or DR-line of the EMBL/SWISSPROT entry
NOTATION : %IDE: percentage of residue identity of the alignment
NOTATION : %SIM (%WSIM): (weighted) similarity of the alignment
NOTATION : IFIR/ILAS: first and last residue of the alignment in the test sequence
NOTATION : JFIR/JLAS: first and last residue of the alignment in the alignend protein
NOTATION : LALI: length of the alignment excluding insertions and deletions
NOTATION : NGAP: number of insertions and deletions in the alignment
NOTATION : LGAP: total length of all insertions and deletions
NOTATION : LSEQ2: length of the entire sequence of the aligned protein
NOTATION : ACCNUM: SwissProt accession number
NOTATION : PROTEIN: one-line description of aligned protein
NOTATION : SeqNo,PDBNo,AA,STRUCTURE,BP1,BP2,ACC: sequential and PDB residue numbers, amino acid (lower case = Cys), secondary
NOTATION : structure, bridge partners, solvent exposure as in DSSP (Kabsch and Sander, Biopolymers 22, 2577-2637(1983)
NOTATION : VAR: sequence variability on a scale of 0-100 as derived from the NALIGN alignments
NOTATION : pair of lower case characters (AvaK) in the alignend sequence bracket a point of insertion in this sequence
NOTATION : dots (....) in the alignend sequence indicate points of deletion in this sequence
NOTATION : SEQUENCE PROFILE: relative frequency of an amino acid type at each position. Asx and Glx are in their
NOTATION : acid/amide form in proportion to their database frequencies
NOTATION : NOCC: number of aligned sequences spanning this position (including the test sequence)
NOTATION : NDEL: number of sequences with a deletion in the test protein at this position
NOTATION : NINS: number of sequences with an insertion in the test protein at this position
NOTATION : ENTROPY: entropy measure of sequence variability at this position
NOTATION : RELENT: relative entropy, i.e. entropy normalized to the range 0-100
NOTATION : WEIGHT: conservation weight
## PROTEINS : identifier and alignment statistics
NR. ID STRID %IDE %WSIM IFIR ILAS JFIR JLAS LALI NGAP LGAP LSEQ2 ACCNUM PROTEIN
1 : F6MZK5_HUMAN 1.00 1.00 1 31 41 71 31 0 0 94 F6MZK5 Insulin (Precursor) OS=Homo sapiens GN=INS PE=2 SV=1
2 : I3WAC9_HUMAN 1.00 1.00 1 31 57 87 31 0 0 110 I3WAC9 Preproinsulin OS=Homo sapiens GN=INS PE=2 SV=1
3 : INS_GORGO 1.00 1.00 1 31 57 87 31 0 0 110 Q6YK33 Insulin OS=Gorilla gorilla gorilla GN=INS PE=3 SV=1
4 : INS_HUMAN 2JZQ 1.00 1.00 1 31 57 87 31 0 0 110 P01308 Insulin OS=Homo sapiens GN=INS PE=1 SV=1
5 : INS_PANTR 1BZV 1.00 1.00 1 31 57 87 31 0 0 110 P30410 Insulin OS=Pan troglodytes GN=INS PE=1 SV=1
6 : INS_PONPY 1.00 1.00 1 31 57 87 31 0 0 110 Q8HXV2 Insulin OS=Pongo pygmaeus GN=INS PE=3 SV=1
7 : Q8HZ80_PONPY 1.00 1.00 1 31 27 57 31 0 0 65 Q8HZ80 Insulin (Fragment) OS=Pongo pygmaeus PE=4 SV=1
8 : Q8HZ81_9PRIM 1.00 1.00 1 31 27 57 31 0 0 65 Q8HZ81 Insulin (Fragment) OS=Gorilla gorilla PE=4 SV=1
9 : INS_CHLAE 0.97 0.97 1 31 57 87 31 0 0 110 P30407 Insulin OS=Chlorocebus aethiops GN=INS PE=1 SV=1
10 : INS_MACFA 0.97 0.97 1 31 57 87 31 0 0 110 P30406 Insulin OS=Macaca fascicularis GN=INS PE=3 SV=1
11 : L9LDU9_TUPCH 0.84 0.87 1 31 57 87 31 0 0 110 L9LDU9 Insulin OS=Tupaia chinensis GN=TREES_T100008383 PE=3 SV=1
12 : INS_AOTTR 0.83 0.92 1 24 57 80 24 0 0 108 P67972 Insulin OS=Aotus trivirgatus GN=INS PE=3 SV=1
13 : F6YAF3_CALJA 0.79 0.92 1 24 57 80 24 0 0 108 F6YAF3 Uncharacterized protein OS=Callithrix jacchus GN=INS-IGF2 PE=3 SV=1
14 : F6QQU6_HORSE 0.77 0.84 1 31 57 87 31 0 0 110 F6QQU6 Insulin OS=Equus caballus GN=INS PE=3 SV=1
15 : G1TTU1_RABIT 0.77 0.87 1 31 57 87 31 0 0 138 G1TTU1 Insulin OS=Oryctolagus cuniculus GN=INS PE=3 SV=2
16 : INS_HORSE 0.77 0.87 1 31 33 63 31 0 0 86 P01310 Insulin OS=Equus caballus GN=INS PE=1 SV=1
17 : INS_RABIT 0.77 0.87 1 31 57 87 31 0 0 110 P01311 Insulin OS=Oryctolagus cuniculus GN=INS PE=1 SV=2
18 : B2KIN7_RHIFE 0.74 0.87 1 31 57 87 31 0 0 110 B2KIN7 Proinsulin (Predicted) OS=Rhinolophus ferrumequinum GN=INS PE=3 SV=1
19 : B7NZU4_RABIT 0.74 0.87 1 31 57 87 31 0 0 110 B7NZU4 Insulin (Predicted) OS=Oryctolagus cuniculus GN=INS PE=3 SV=1
20 : INS_CANFA 0.74 0.90 1 31 57 87 31 0 0 110 P01321 Insulin OS=Canis familiaris GN=INS PE=1 SV=1
21 : INS_RODSP 0.74 0.81 1 31 57 87 31 0 0 108 P21563 Insulin OS=Rodentia sp. GN=INS PE=3 SV=1
22 : INS_SPETR 0.74 0.81 1 31 57 87 31 0 0 110 Q91XI3 Insulin OS=Spermophilus tridecemlineatus GN=INS PE=3 SV=1
23 : A0ELY6_9MURI 0.71 0.77 1 31 57 87 31 0 0 110 A0ELY6 Preproinsulin 2 OS=Rattus losea GN=Ins2 PE=3 SV=1
24 : A0ELY7_APOSM 0.71 0.81 1 31 57 87 31 0 0 110 A0ELY7 Preproinsulin 2 OS=Apodemus semotus GN=Ins2 PE=3 SV=1
25 : A0ELY8_MUSCR 0.71 0.81 1 31 57 87 31 0 0 110 A0ELY8 Preproinsulin 2 OS=Mus caroli GN=Ins2 PE=3 SV=1
26 : D0EY27_MOUSE 0.71 0.81 1 31 57 87 31 0 0 109 D0EY27 Insulin-2 (Fragment) OS=Mus musculus GN=Ins2 PE=2 SV=1
27 : INS2_MOUSE 0.71 0.81 1 31 57 87 31 0 0 110 P01326 Insulin-2 OS=Mus musculus GN=Ins2 PE=1 SV=1
28 : INS2_RAT 0.71 0.81 1 31 57 87 31 0 0 110 P01323 Insulin-2 OS=Rattus norvegicus GN=Ins2 PE=1 SV=1
29 : INS_CAVPO 0.71 0.77 1 31 57 87 31 0 0 110 P01329 Insulin OS=Cavia porcellus GN=INS PE=1 SV=2
30 : L5KR12_PTEAL 0.71 0.84 1 31 57 87 31 0 0 110 L5KR12 Insulin OS=Pteropus alecto GN=PAL_GLEAN10011204 PE=3 SV=1
31 : Q2IDG8_MUSSP 0.71 0.81 1 31 57 87 31 0 0 110 Q2IDG8 Insulin II OS=Mus spretus GN=INS2 PE=3 SV=1
32 : Q5EEX1_MOUSE 0.71 0.81 1 31 57 87 31 0 0 110 Q5EEX1 Insulin II OS=Mus musculus GN=Ins2 PE=3 SV=1
33 : A0ELZ1_VOLKI 0.70 0.80 2 31 58 87 30 0 0 110 A0ELZ1 Preproinsulin OS=Volemys kikuchii GN=Ins PE=3 SV=1
34 : G3HXZ8_CRIGR 0.70 0.77 2 31 196 225 30 0 0 248 G3HXZ8 Insulin OS=Cricetulus griseus GN=I79_015914 PE=3 SV=1
35 : A0ELY9_9MURI 0.68 0.77 1 31 57 87 31 0 0 110 A0ELY9 Preproinsulin 2 OS=Niviventer coninga GN=Ins2 PE=3 SV=1
36 : INS1_RAT 0.68 0.74 1 31 57 87 31 0 0 110 P01322 Insulin-1 OS=Rattus norvegicus GN=Ins1 PE=1 SV=1
37 : INS_FELCA 0.68 0.84 1 31 57 87 31 0 0 110 P06306 Insulin OS=Felis catus GN=INS PE=1 SV=2
38 : M3Y2P2_MUSPF 0.68 0.87 1 31 57 86 31 1 1 109 M3Y2P2 Uncharacterized protein OS=Mustela putorius furo GN=INS PE=3 SV=1
39 : Q52PU3_FELCA 0.68 0.84 1 31 33 63 31 0 0 86 Q52PU3 Preproinsulin (Fragment) OS=Felis catus PE=2 SV=1
40 : INS_CRILO 0.67 0.80 2 31 58 87 30 0 0 110 P01313 Insulin OS=Cricetulus longicaudatus GN=INS PE=1 SV=2
41 : A0ELY2_9MURI 0.65 0.74 1 31 57 87 31 0 0 110 A0ELY2 Preproinsulin 1 OS=Rattus losea GN=Ins1 PE=3 SV=1
42 : A0ELY5_9MURI 0.65 0.74 1 31 57 87 31 0 0 110 A0ELY5 Preproinsulin 1 OS=Niviventer coninga GN=Ins1 PE=3 SV=1
43 : G5C2F2_HETGA 0.65 0.74 1 31 57 87 31 0 0 110 G5C2F2 Insulin OS=Heterocephalus glaber GN=GW7_00389 PE=3 SV=1
44 : INS_CHICH 0.65 0.71 1 31 33 63 31 0 0 86 P01327 Insulin OS=Chinchilla chinchilla GN=INS PE=1 SV=2
45 : A0ELZ0_MERUN 0.63 0.80 2 31 58 87 30 0 0 110 A0ELZ0 Preproinsulin OS=Meriones unguiculatus GN=Ins PE=3 SV=1
46 : A0ELY3_APOSM 0.61 0.77 1 31 57 87 31 0 0 110 A0ELY3 Preproinsulin 1 OS=Apodemus semotus GN=Ins1 PE=3 SV=1
## ALIGNMENTS 1 - 46
SeqNo PDBNo AA STRUCTURE BP1 BP2 ACC NOCC VAR ....:....1....:....2....:....3....:....4....:....5....:....6....:....7
1 1 A E 0 0 201 43 0 EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE EEEEE EEEE E
2 2 A A > + 0 0 50 47 57 AAAAAAAAAAVAAAVAVVVVVVVVVVVVLLVVVVVVAAAVVVLLVV
3 3 A E T 3> S+ 0 0 144 47 0 EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE
4 4 A D T 34 S+ 0 0 134 47 12 DDDDDDDDDDDDDDEDEDEDDEDDDDDDDGDDDDDDDDDDDDNDDD
5 5 A L T <4 S- 0 0 97 47 74 LLLLLLLLPPSLLPLPLPLLPQPPPPPPPPPPPPPPLLLPPPLPPP
6 6 A Q T >4> - 0 0 62 47 0 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
7 7 A V T 3<5 - 0 0 57 47 28 VVVVVVVVVVVVVVVVVAVVVGVVVVVVVGVVVVVVGAGVVVVVMV
8 8 A G T 3 5S+ 0 0 16 47 57 GGGGGGGGGGGGGGGGGGGRGGAAAAAAEGAAATPPKRKAPAGGPE
9 9 A Q T < 5S+ 0 0 124 47 16 QQQQQQQQQQQQQQQEQQQDQQQQQQQQQEQQQQQQDDDQQQQQQQ
10 10 A V T 5S- 0 0 104 47 64 VVVVVVVVVVVVVEAVAVAVVVQLLLLLTVLLLLLLASALLLAALL
11 11 A E S S+ 0 0 20 47 23 GGGGGGGGGGGGGGGGGGGAGGGGGGGGGGGGGGGGAAAGSGGVSA
16 16 A P T 3 S+ 0 0 131 47 20 PPPPPPPPPPPSSPPPPPPPPPPPPPPPLPPPPPPPPPPPPPLPPP
17 17 A G T 3 S+ 0 0 83 47 29 GGGGGGGGGGGIIGGGGGDGGGGGGGGGGGGGGGGEGGGGEEEEGG
18 18 A A S < S- 0 0 37 47 29 AAAAAAAAAAATTLALATAEAAAAAAAAAAAAAATAAAAAAAAAAT
19 19 A G S S- 0 0 17 47 2 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGDGGGGGG
20 20 A S S S- 0 0 62 47 62 SSSSSSSSSSSSSGGGGGGGSLDDDDDDGSDDDDDDGGGDDDGRDD
21 21 A L - 0 0 91 47 17 LLLLLLLLLLLLLLLLLLLLEPLLLLLLLRLLLLLLLLLLLLLLLL
22 22 A Q S > >S+ 0 0 99 46 11 QQQQQQQQQQQPPQQQQQQQQQQQQQQQQQQQQQQQQ.QQQQQQQE
23 23 A P G > 5S+ 0 0 73 47 54 PPPPPPPPPPPPAPPPPSPPTPTTTTTTPATTTTTTPAPTTTPPAT
24 24 A L G 3 5S+ 0 0 126 47 30 LLLLLLLLLLLLLLSLSLSLLLLLLLLLLLLLLLLLSLSLLLLLLL
25 25 A A G < 5S- 0 0 16 45 3 AAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAGAAAAAAAA
26 26 A L T < 5S+ 0 0 155 45 7 LLLLLLLLLLL LLLLLLLLLLLLLLLLLLLLLLLLLLLLLQLLL
27 27 A E >< + 0 0 72 45 8 EEEEEEEEEEE AEAEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE
28 28 A G T 4 S- 0 0 45 45 70 GGGGGGGGGGV GLGLGLGVMVVVVVVMGVVVVVVAGAVVVLMVV
29 29 A S T 4 S- 0 0 112 45 49 SSSSSSSSSSP PAPAPAAAAAAAAAAAPAAAAAAPAPAAAATAA
30 30 A L T 4 0 0 149 45 83 LLLLLLLLLLP QLQLPLLRLRRQQQRLPQQQQRRLLLQRRLLRR
31 31 A Q < 0 0 154 45 0 QQQQQQQQQQQ QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
## SEQUENCE PROFILE AND ENTROPY
SeqNo PDBNo V L I M F W Y G A P S T C H R K Q E N D NOCC NDEL NINS ENTROPY RELENT WEIGHT
1 1 A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 43 0 0 0.000 0 1.00
2 2 A 53 9 0 0 0 0 0 0 38 0 0 0 0 0 0 0 0 0 0 0 47 0 0 0.913 30 0.43
3 3 A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 47 0 0 0.000 0 1.00
4 4 A 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 9 2 87 47 0 0 0.493 16 0.88
5 5 A 0 40 0 0 0 0 0 0 0 55 2 0 0 0 0 0 2 0 0 0 47 0 0 0.857 28 0.26
6 6 A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 47 0 0 0.000 0 1.00
7 7 A 85 0 0 2 0 0 0 9 4 0 0 0 0 0 0 0 0 0 0 0 47 0 0 0.563 18 0.71
8 8 A 0 0 0 0 0 0 0 53 23 9 0 2 0 0 4 4 0 4 0 0 47 0 0 1.370 45 0.42
9 9 A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 87 4 0 9 47 0 0 0.463 15 0.84
10 10 A 43 34 0 0 0 0 0 0 15 0 2 2 0 0 0 0 2 2 0 0 47 0 0 1.342 44 0.36
11 11 A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 98 0 2 47 0 0 0.103 3 0.98
12 12 A 0 96 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 47 0 0 0.176 5 0.85
13 13 A 0 0 0 0 0 0 0 98 2 0 0 0 0 0 0 0 0 0 0 0 47 0 0 0.103 3 0.97
14 14 A 2 0 0 4 0 0 0 85 2 0 0 0 0 0 0 0 0 6 0 0 47 0 0 0.611 20 0.70
15 15 A 2 0 0 0 0 0 0 83 11 0 4 0 0 0 0 0 0 0 0 0 47 0 0 0.609 20 0.77
16 16 A 0 4 0 0 0 0 0 0 0 91 4 0 0 0 0 0 0 0 0 0 47 0 0 0.350 11 0.79
17 17 A 0 0 4 0 0 0 0 83 0 0 0 0 0 0 0 0 0 11 0 2 47 0 0 0.609 20 0.71
18 18 A 0 4 0 0 0 0 0 0 83 0 0 11 0 0 0 0 0 2 0 0 47 0 0 0.609 20 0.71
19 19 A 0 0 0 0 0 0 0 98 0 0 0 0 0 0 0 0 0 0 0 2 47 0 0 0.103 3 0.98
20 20 A 0 2 0 0 0 0 0 26 0 0 34 0 0 0 2 0 0 0 0 36 47 0 0 1.247 41 0.37
21 21 A 0 94 0 0 0 0 0 0 0 2 0 0 0 0 2 0 0 2 0 0 47 1 0 0.308 10 0.82
22 22 A 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 93 2 0 0 46 0 0 0.283 9 0.89
23 23 A 0 0 0 0 0 0 0 0 9 53 2 36 0 0 0 0 0 0 0 0 47 0 0 0.995 33 0.45
24 24 A 0 89 0 0 0 0 0 0 0 0 11 0 0 0 0 0 0 0 0 0 47 0 0 0.339 11 0.69
25 25 A 0 0 0 0 0 0 0 2 98 0 0 0 0 0 0 0 0 0 0 0 45 0 0 0.107 3 0.97
26 26 A 0 98 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 45 0 0 0.107 3 0.93
27 27 A 0 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 96 0 0 45 0 0 0.182 6 0.92
28 28 A 42 9 0 7 0 0 0 38 4 0 0 0 0 0 0 0 0 0 0 0 45 0 0 1.266 42 0.30
29 29 A 0 0 0 0 0 0 0 0 58 16 24 2 0 0 0 0 0 0 0 0 45 0 0 1.035 34 0.50
30 30 A 0 49 0 0 0 0 0 0 0 7 0 0 0 0 22 0 22 0 0 0 45 0 0 1.199 40 0.16
31 31 A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 45 0 0 0.000 0 1.00
## INSERTION LIST
AliNo IPOS JPOS Len Sequence
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